The Great Tree

taniith · Great Tree Member Joined: 22 Dec 2003 Posts: 98

Well, it looks like Chris has decided to join our fair forums.

Welcome Chris! Very Happy

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Durin Mephit · Posted: Sat Feb 04, 2006 12:23 pm Post subject:

Shorah, Chris. Smile

brian · Posted: Sat Feb 04, 2006 12:46 pm Post subject:

Hopefully he'll feel more welcome here than he does at drcsite.
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Professor Askew · Posted: Sat Feb 04, 2006 1:56 pm Post subject:

Welcome, Chris! I'd offer my assistance if I knew what you were up to.....if anything. Wink

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Ashtar · Posted: Sat Feb 04, 2006 8:05 pm Post subject:

Shorah Chris! Welcome to the Great Tree. Please, if you hear anything from the DRC and what they are up to, we would love to know Smile

Ashtar
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Chris Clement · Posted: Sun Feb 05, 2006 4:39 am Post subject:

Hello! Thank you very much, members of the Great Tree. It's good to know you all. Hmmm... Professor, do you know anything about repairing diamondoid films? Funny things they want me to do up here. But, I regret to mention that I am no longer involved in the restoration project at the moment, I have found new employers. I am unfortunately only somewhat more 'in-the-loop' than everyone else. I am, more than my share, confused with the many of the actions of the DRC.

Still, thank you, and have a good night,
Chris

Mystlander · Posted: Sun Feb 05, 2006 8:30 pm Post subject:

Welcome to The Great Tree, Chris!

Perhaps this information will be helpful...

Quote:

Future experiments must determine if ordinary diamondoid surfaces will have to be supplemented with additional antithrombogenic coatings in order to achieve medical nanorobot mission objectives. If such coatings are required, one simple possibility is surface-immobilized heparin, a ~15 kD straight-chain anionic (acidic) mucopolysaccharide (glycosaminoglycan) that forms polymers of various lengths. Heprin inhibits coagulation primarily by enhancing about ~1000 times the ability of antithrombin to inactivate a number of coagulation enzymes, including thrombin and activated factors X, XII, XI, and IX. Nanorobot exteriors could be “heparinized” and thereby rendered thromboresistant by immobilized heparin on all blood-contacting surfaces at ~monolayer surface concentrations (e.g., 7-10 pmol/cm2. Cellulose membranes coated with 3.6 pmol/cm2 of endothelial-cell-surface heparin sulfate show complete inhibition of platelet adhesion. Albumin-heparin conjugate coated surfaces also display anticoagulant activity – pre-adhered endothelial cells proliferating on this coating significantly reduce the number of platelets which subsequently adhere to the surface, and other immobilized heparin conjugates have also given promising results. Unfortunately, heparin can have undesirable side effects such as binding with platelet factor 4, which then induces associated antibody production leading to thrombocytopenia, so a synthetic heparin-like analog may need to be engineered with properties similar to low molecular weight heparin (e.g., enoxiparin which decreases risk of HITT (heparin-induced thrombosis) syndrome. Coatings of hydrophilic acrylic copolymers with salicylic acid residues have also given good antithrombogenic behavior in animal studies, and hirudin-thrombin complex adsorbed on glass bead surface did not stimulate fibrinogen activation. Polyethylene electret film has even been studied for its athrombogenic properties.

Mystlander
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Professor Askew · Posted: Mon Feb 06, 2006 2:26 am Post subject:

Wow, Mystlander. That's exactly what I was going to say. Were you reading my book? Shocked

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Chris Clement · Posted: Mon Feb 06, 2006 7:16 pm Post subject:

Not to put you down, but I'm working less on nanotech and more on D'ni tech. You wouldn't think so, but its almost more complicated. Thanks though. I think they'll leave me alone about the issue soon.

Eleri · Great Tree Member Joined: 27 May 2004 Posts: 819

is it bad that I understood most of that?

Eleri, avoiding writing a paper on anemia.
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Professor Askew · Posted: Mon Feb 06, 2006 8:42 pm Post subject:

Now I'm really curious......
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Vormaen · Posted: Mon Feb 06, 2006 10:38 pm Post subject:

Hmmmm......so Chris, what was you duty as a reseng during the DRC's first bout?
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ghaelen · Posted: Wed Feb 08, 2006 12:55 pm Post subject:

LOL Eleri, I was just going to say that!

Or else I don't but so many large unintelligble words just seem comfortable for me to see anymore.

What was that song....Confounding me with science....?
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brian · Posted: Thu Feb 09, 2006 7:03 pm Post subject:

Quote the DRC:

Ashtar · Posted: Thu Feb 09, 2006 8:23 pm Post subject:

*Sigh* Just when you let your guard down, something like this happens. Now it will be even harder for me to trust someone who is truly a ResEng or affiliated with the DRC.

For your own sake Chris, you had better come clean. If you come out and admit your mistake, we are more willing to forgive. However, if you don't and can't come up with some kind of proof that your are truly a ResEng, then I wouldn't want to be in your shoes.

I wish we would hear something from Sharper.

Ashtar
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